Uncovering Latent Communication Patterns in Brain Networks via Adaptive Flow Routing

Tóm tắt (nguồn: OpenReview · © tác giả)

Unraveling how macroscopic cognitive phenotypes emerge from microscopic neuronal connectivity remains one of the core pursuits of neuroscience. To this end, researchers typically leverage multi-modal information from structural connectivity (SC) and functional connectivity (FC) to complete downstream tasks. Recent methodologies explore the intricate coupling mechanisms between SC and FC, attempting to fuse their representations at the regional level. However, while these approaches do incorporate useful neuroscientific observations, they predominantly operate at a topological or architectural level and lack a principled formulation grounded in neural communication dynamics. Consequently, they are limited in quantifying how information is actually routed between neural regions, and thus cannot fully explain why SC and FC exhibit dynamic states of both coupling and heterogeneity. In this paper, we formulate multi-modal fusion through the lens of neural communication dynamics and propose the Adaptive Flow Routing Network (AFR-Net), a physics-informed framework that models how structural constraints give rise to functional communication patterns, enabling interpretable discovery of critical neural pathways. Extensive experiments demonstrate that AFR-Net significantly outperforms state-of-the-art baselines. The code is available at \url{https://github.com/Skyyyy0920/AFR-Net}.

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